SCHEMBL3933757

SCHEMBL3933757

Cc1c(C#N)cccc1CC#N

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.43
NISCH Q9Y2I1 1/20 0.41
ALDH1A1 P00352 3/20 0.38
HPGD P15428 1/20 0.38
LRRK2 Q5S007 1/20 0.37
ENPP2 Q13822 1/20 0.34
CYP19A1 P11511 1/20 0.34
FFAR1 O14842 1/20 0.34
FFAR4 Q5NUL3 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
MAPT P10636 1/20 0.33
MAOB P27338 1/20 0.33
NR3C1 P04150 1/20 0.33
ADORA2A P29274 1/20 0.33
POLB P06746 1/20 0.33
GAA P10253 1/20 0.33
ALOX15 P16050 1/20 0.33
ATM Q13315 1/20 0.33
HSD17B10 Q99714 1/20 0.33
TP53 P04637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28380698 0.87 ALDH1A1 (0.45) ALDH1A1HPGDENPP2FFAR1FFAR4
SCHEMBL8855696 0.83 TSHR (0.46) TSHRNISCHALDH1A1LRRK2CYP19A1
SCHEMBL11967122 0.82 TSHR (0.45) TSHRNISCHALDH1A1LRRK2MAOB
SCHEMBL6354890 0.80 TSHR (0.43) TSHRNISCHALDH1A1LRRK2CYP19A1
SCHEMBL15898401 0.80 TSHR (0.43) TSHRNISCHALDH1A1LRRK2CYP19A1
Water SCHEMBL8703021 0.80 TSHR (0.43) TSHRNISCHALDH1A1LRRK2CYP19A1
SCHEMBL2134106 0.80 PDCD1 (0.48) TSHRNISCHALDH1A1LRRK2SMN1; SMN2
SCHEMBL31667703 0.80 TSHR (0.43) TSHRNISCHALDH1A1LRRK2CYP19A1
SCHEMBL8700310 0.80 TSHR (0.43) TSHRNISCHALDH1A1LRRK2CYP19A1
SCHEMBL3792645 0.79 ESR1 (0.41) TSHRALDH1A1HPGDENPP2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2044037-A2 HIV REVERSE TRANSCRIPTASE INHIBITORS Gilead Sciences, Inc. (US) 2009-04-08 EP disclosed
WO-2008016522-A2 HIV REVERSE TRANSCRIPTASE INHIBITORS GILEAD SCIENCES, INC. (US) 2008-02-07 WO disclosed