Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940654 | 0.82 | TDP1 (0.59) | TDP1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4788119 | 0.82 | TDP1 (0.59) | TDP1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4933726 | 0.80 | TDP1 (0.74) | TDP1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3168587 | 0.80 | TDP1 (0.74) | TDP1KMT2AMEN1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL3239786 | 0.79 | TDP1 (0.72) | TDP1KMT2AMEN1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL3239776 | 0.79 | TDP1 (0.72) | TDP1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL9501912 | 0.79 | HPGD (0.54) | TDP1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL27652972 | 0.78 | TDP1 (0.59) | TDP1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL14046234 | 0.75 | TDP1 (0.71) | TDP1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4939844 | 0.74 | TDP1 (0.69) | TDP1KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014674-A1 | HETEROCYCLYLAMIDES AS GUT MICROSOMAL TRIGLYCERIDE TRANSPORT PROTEIN INHIBITORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |