Flutamide

Flutamide

SCHEMBL3934

CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AR

The experimentally established mechanism targets of Flutamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR known ✓ P10275 8/20 1.00
CYP3A4 P08684 2/20 1.00
CES2 O00748 1/20 1.00
ABCB11 O95342 1/20 1.00
ALDH1A1 P00352 1/20 1.00
LMNA P02545 1/20 1.00
CYP1A2 P05177 1/20 1.00
GLA P06280 1/20 1.00
ADORA3 P0DMS8 1/20 1.00
CHRM1 P11229 1/20 1.00
CYP2C9 P11712 1/20 1.00
ALOX15 P16050 1/20 1.00
TSHR P16473 1/20 1.00
TBXA2R P21731 1/20 1.00
AADAC P22760 1/20 1.00
MAPK1 P28482 1/20 1.00
CYP2C19 P33261 1/20 1.00
ADRA1A P35348 1/20 1.00
HTT P42858 1/20 1.00
HTR6 P50406 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flutamide SCHEMBL1461845 1.00 AR (1.00) ARCYP3A4CES2ABCB11ALDH1A1
Flutamide SCHEMBL29349783 1.00 AR (1.00) ARCYP3A4CES2ABCB11ALDH1A1
Flutamide SCHEMBL28162762 0.99 AR (0.97) ARCYP3A4CES2ABCB11ALDH1A1
Flutamide SCHEMBL21753660 0.99 AR (0.97) ARCYP3A4CES2ABCB11ALDH1A1
Flutamide SCHEMBL679388 0.96 AR (0.93) ARCYP3A4CES2ABCB11ALDH1A1
Flutamide SCHEMBL7104567 0.95 AR (0.90) ARCYP3A4CES2ABCB11ALDH1A1
Flutamide SCHEMBL1028216 0.93 AR (0.86) ARCYP3A4CES2ABCB11ALDH1A1
SCHEMBL11512367 0.91 AR (0.83) ARCYP3A4CES2ABCB11ALDH1A1
SCHEMBL19117466 0.90 AR (0.81) ARCYP3A4CES2ABCB11ALDH1A1
SCHEMBL11512254 0.90 AR (0.81) ARCYP3A4CES2ABCB11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 105522 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
EP-4746898-A2 IDENTIFICATION OF SEQUENCE VARIANTS OF THE ERVMER34-1 SEQUENCE FAMILY AND USE IN ANTI-CANCER THERAPIES The United States of America, as represented by the Secretary, Department of Health and Human Services (US) 2026-05-27 EP claimed
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
EP-4467200-B1 EZH2 INHIBITION THERAPIES FOR THE TREATMENT OF ANDROGEN RECEPTOR MUTATED PROSTATE CANCERS CONSTELLATION PHARMACEUTICALS INC (US) 2026-05-27 EP claimed
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
WO-2026105121-A1 ANTICANCER FORMULATIONS AND USES THEREOF INTRAGEL THERAPEUTICS LTD. (IL) 2026-05-21 WO claimed
US-20260137678-A1 METHODS FOR TREATING OR PREVENTING NEUROENDOCRINE TUMOR FORMATION USING XPO1 INHIBITORS MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2026-05-21 US claimed
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
EP-4745155-A1 POWDER CONTAINING PARTICLES OF GELATIN DERIVATIVE AND APPLICATION OF SAME IN MEDICAL TREATMENT National Institute for Materials Science (JP) 2026-05-20 EP claimed
CN-122070133-A Pharmaceutical compositions containing androgen receptor inhibitors/antagonists, methods and uses 苏州开拓药业股份有限公司 2026-05-19 CN claimed
US-4598072-A Combinations of an aromatase-inhibitor and an antiandrogen for prophylaxis and/or treatment of benign prostatic hyperplasia SCHERING AKTIENGESELLSCHAFT (DE) 1986-07-01 US claimed
WO-1986001105-A1 PHARMACEUTICAL COMPOSITION FOR COMBINATION THERAPY OF HORMONE DEPENDENT CANCERS LABRIE FERNAND (CA) 1986-02-27 WO claimed
US-4474813-A PROSTATIC CARCINOMA SCHERING CORPORATION (US) 1984-10-02 US claimed
US-4472382-A Treatment method ROUSSEL UCLAF (FR) 1984-09-18 US claimed
US-4329364-A Antiandrogenic agents and methods for the treatment of androgen dependent disease states SCHERING CORPORATION (US) 1982-05-11 US claimed
US-4302599-A Process for nitrating anilides SCHERING CORPORATION (US) 1981-11-24 US claimed
US-4161540-A SUBSTITUTED ANILIDE SCHERING CORPORATION (US) 1979-07-17 US claimed
US-4139638-A NITRO OR HALOGEN SUBSTITUTED ANILIDES, ANTIANDROGENS, ACNE, CANCER SCHERING CORPORATION (US) 1979-02-13 US claimed
US-4039684-A 4-NITRO-3-TRIFLUOROMETHYL-ISOBUTYRANILIDE OR CORRESPONDING 2-HYDROXY- COMPOUND SCHERING CORPORATION (US) 1977-08-02 US claimed
US-3995060-A SUBSTITUTED ANILIDES SCHERING CORPORATION (US) 1976-11-30 US claimed