Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930318 | 0.95 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL29290659 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL5541355 | 0.83 | ALDH1A1 (0.62) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL1841787 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL21059029 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL21059231 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL21059102 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL21059191 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL21059105 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL21059265 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043644-A1 | NF- B INHIBITOR | Otsuka Pharmaceutical Co., Ltd. (JP) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008010601-A1 | NF- ϰB INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-01-24 | — | — | WO | disclosed |