Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 10/20 | 0.59 |
| ▸ | BRAF | P15056 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943927 | 0.90 | BRAF (0.56) | CSF1RBRAFCYP2C9JAK2PDGFRB | |
| SCHEMBL3930153 | 0.87 | CSF1R (0.51) | CSF1RBRAFMEN1KMT2ACYP2C9 | |
| SCHEMBL3933564 | 0.83 | CSF1R (0.47) | CSF1RBRAFCYP2C9JAK2PDGFRB | |
| SCHEMBL3934259 | 0.80 | BRAF (0.82) | CSF1RBRAFCYP2C9JAK2PDGFRB | |
| SCHEMBL3930169 | 0.77 | CSF1R (0.62) | CSF1RBRAFMEN1KMT2AKCNQ3 | |
| SCHEMBL4170151 | 0.75 | BRAF (0.53) | BRAFCYP2C9MAPK14 | |
| SCHEMBL3936904 | 0.74 | CSF1R (1.00) | CSF1RBRAFMEN1KMT2AKCNQ3 | |
| SCHEMBL4750556 | 0.74 | BRAF (0.67) | CSF1RBRAFCYP2C9 | |
| SCHEMBL3934373 | 0.74 | BRAF (0.71) | CSF1RBRAFCYP2C9MAPK14 | |
| SCHEMBL3936045 | 0.73 | BRAF (0.62) | CSF1RBRAFMEN1KMT2AKCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |