Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 15/20 | 0.47 |
| ▸ | BRAF | P15056 | 6/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943927 | 0.84 | BRAF (0.56) | CSF1RBRAFCYP2C9JAK2PDGFRB | |
| SCHEMBL3934263 | 0.83 | CSF1R (0.59) | CSF1RBRAFCYP2C9JAK2PDGFRB | |
| SCHEMBL3930153 | 0.82 | CSF1R (0.51) | CSF1RBRAFCYP2C9JAK2PDGFRB | |
| SCHEMBL3933559 | 0.81 | BRAF (0.66) | CSF1RBRAFCYP2C9JAK2PDGFRB | |
| SCHEMBL4170151 | 0.76 | BRAF (0.53) | BRAFCYP2C9MAPK14 | |
| SCHEMBL3937355 | 0.74 | BRAF (0.49) | CSF1RBRAFMAPK14 | |
| SCHEMBL3638332 | 0.73 | KMT2A (0.58) | — | |
| SCHEMBL5211619 | 0.72 | BRAF (0.45) | BRAFCYP2C9 | |
| SCHEMBL12302992 | 0.70 | HTT (0.61) | CSF1RBRAFCYP2C9 | |
| SCHEMBL3944021 | 0.70 | BRAF (0.82) | CSF1RBRAFCYP2C9JAK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |