Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 8/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3601249 | 0.83 | DPP4 (0.61) | DPP4DPP8DPP7CYP2D6DPP9 | |
| SCHEMBL3940298 | 0.81 | DPP4 (0.56) | DPP4DPP8DPP7CYP2D6DPP9 | |
| SCHEMBL6820877 | 0.80 | DPP4 (0.58) | DPP4DPP8DPP7CYP2D6DPP9 | |
| SCHEMBL1597146 | 0.80 | DPP4 (0.58) | DPP4DPP8DPP7CYP2D6DPP9 | |
| SCHEMBL15272243 | 0.80 | IKBKB (0.50) | DPP4DPP8DPP7CYP2D6DPP9 | |
| SCHEMBL14421656 | 0.77 | DPP4 (0.70) | DPP4DPP8DPP7CYP2D6DPP9 | |
| SCHEMBL2906959 | 0.76 | CYP2D6 (0.38) | DPP4DPP8DPP7CYP2D6DPP9 | |
| SCHEMBL15254493 | 0.75 | IKBKB (0.50) | DPP4DPP8DPP7CYP2D6DPP9 | |
| SCHEMBL1597359 | 0.74 | CYP2D6 (0.47) | DPP4DPP8DPP7CYP2D6DPP9 | |
| SCHEMBL1597361 | 0.74 | CYP2D6 (0.47) | DPP4DPP8DPP7CYP2D6DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |