Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939845 | 0.89 | GPR119 (0.54) | GPR119 | |
| SCHEMBL3927520 | 0.88 | GPR119 (0.58) | GPR119HRH3KDM1A | |
| SCHEMBL4102858 | 0.86 | GPR119 (0.60) | GPR119KDM1A | |
| SCHEMBL4492217 | 0.86 | GPR119 (0.73) | GPR119KDM1A | |
| SCHEMBL3938260 | 0.85 | GPR119 (0.79) | GPR119 | |
| SCHEMBL3931348 | 0.85 | GPR119 (0.59) | GPR119HRH3KDM1A | |
| SCHEMBL3929937 | 0.85 | GPR119 (0.61) | GPR119KDM1A | |
| SCHEMBL3930850 | 0.77 | GPR119 (0.61) | GPR119 | |
| SCHEMBL3939506 | 0.77 | GPR119 (0.67) | GPR119KDM1A | |
| SCHEMBL11384800 | 0.77 | GPR119 (0.80) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043744-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2008008887-A2 | GPR119 AGONISTS FOR TREATING METABOLIC DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | claimed |
| EP-2043744-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008895-A1 | GPR119 AGONISTS FOR THE TREATMENT OF DIABETES AND RELATED DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008008887-A2 | GPR119 AGONISTS FOR TREATING METABOLIC DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |