Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943990 | 0.84 | BRAF (0.57) | BRAFCYP2C9MAPK14CSF1RJAK2 | |
| SCHEMBL3933230 | 0.83 | BRAF (0.48) | BRAFCYP2C9CSF1R | |
| SCHEMBL3934840 | 0.80 | BRAF (0.78) | BRAFCYP2C9MAPK14CSF1RJAK2 | |
| SCHEMBL3937355 | 0.80 | BRAF (0.49) | BRAFMAPK14CSF1RKDR | |
| SCHEMBL3931460 | 0.79 | BRAF (0.71) | BRAFCYP2C9MAPK14CSF1RJAK2 | |
| SCHEMBL4749868 | 0.78 | BRAF (0.67) | BRAFCYP2C9MAPK14CSF1RJAK2 | |
| SCHEMBL3931831 | 0.76 | BRAF (0.81) | BRAFCYP2C9MAPK14CSF1RJAK2 | |
| SCHEMBL4749967 | 0.75 | BRAF (0.57) | BRAFCYP2C9MAPK14CSF1RJAK2 | |
| SCHEMBL3942817 | 0.75 | BRAF (1.00) | BRAFCYP2C9MAPK14CSF1RJAK2 | |
| SCHEMBL3943350 | 0.74 | BRAF (0.81) | BRAFCYP2C9MAPK14CSF1RJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008120004-A1 | COMBINATION OF A MEK- INHIBITOR AND A B-RAF INHIBITOR FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | claimed |
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |