Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 14/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3937348 | 0.80 | BRAF (0.64) | BRAFCSF1RKDRKITMAPK14 | |
| SCHEMBL3934844 | 0.80 | BRAF (0.60) | BRAFCSF1RKDRMAPK14 | |
| SCHEMBL3941819 | 0.74 | BRAF (0.83) | BRAFCSF1RKDRKITMAPK14 | |
| SCHEMBL3933564 | 0.74 | CSF1R (0.47) | BRAFCSF1RMAPK14 | |
| SCHEMBL3933230 | 0.74 | BRAF (0.48) | BRAFCSF1R | |
| SCHEMBL3933304 | 0.72 | MAPK14 (0.72) | BRAFCSF1RKDRKITMAPK14 | |
| SCHEMBL3943927 | 0.70 | BRAF (0.56) | BRAFCSF1RMAPK14 | |
| SCHEMBL3934263 | 0.69 | CSF1R (0.59) | BRAFCSF1RMAPK14TP53MEN1 | |
| SCHEMBL3930153 | 0.68 | CSF1R (0.51) | BRAFCSF1RMAPK14SMN1; SMN2MEN1 | |
| SCHEMBL3935825 | 0.66 | CSF1R (0.75) | BRAFCSF1RNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |