Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 1/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.61 |
| ▸ | BRAF | P15056 | 15/20 | 0.61 |
| ▸ | RAF1 | P04049 | 4/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933053 | 0.84 | SMN1; SMN2 (0.60) | MAPK14BRAFRAF1CSF1R | |
| SCHEMBL6267100 | 0.84 | MAPK14 (0.52) | TEKMAPK14BRAFRAF1MAPK13 | |
| SCHEMBL12764085 | 0.83 | MAPK14 (0.69) | MAPK14BRAFRAF1MAPK13 | |
| SCHEMBL6251957 | 0.81 | MAPK14 (0.56) | MAPK14BRAFRAF1MAPK13 | |
| SCHEMBL31524076 | 0.81 | MAPK14 (0.66) | MAPK14BRAFRAF1MAPK13 | |
| SCHEMBL4827539 | 0.81 | MAPK14 (0.66) | MAPK14BRAFRAF1MAPK13 | |
| SCHEMBL12763857 | 0.80 | MAPK13 (0.61) | MAPK14BRAFRAF1MAPK13 | |
| SCHEMBL3932223 | 0.80 | BRAF (0.71) | BRAFCSF1R | |
| SCHEMBL12764177 | 0.80 | MAPK14 (0.65) | MAPK14BRAFRAF1MAPK13 | |
| SCHEMBL3218969 | 0.79 | ABL1 (0.71) | TEKMAPK14BRAFRAF1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |