Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | BRAF | P15056 | 13/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 2/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941868 | 0.91 | BRAF (0.61) | SMN1; SMN2TP53BRAFMAPTPOLB | |
| SCHEMBL3934865 | 0.84 | TEK (0.64) | BRAFCSF1RRAF1MAPK14 | |
| SCHEMBL27720606 | 0.81 | BRAF (0.79) | BRAFCSF1RMAPK14 | |
| SCHEMBL27699867 | 0.80 | BRAF (0.69) | BRAFCSF1RRAF1MAPK14 | |
| SCHEMBL3932223 | 0.79 | BRAF (0.71) | SMN1; SMN2BRAFMAPTPOLBMEN1 | |
| SCHEMBL13492316 | 0.78 | ABL1 (0.68) | BRAFCSF1RRAF1MAPK14 | |
| SCHEMBL3941714 | 0.77 | BRAF (0.83) | BRAFCSF1RMAPK14 | |
| SCHEMBL3937724 | 0.77 | CSF1R (0.83) | BRAFCSF1RMAPK14 | |
| SCHEMBL13162883 | 0.76 | ABL1 (0.56) | SMN1; SMN2TP53BRAFMAPTPOLB | |
| SCHEMBL3936032 | 0.76 | CSF1R (0.66) | SMN1; SMN2TP53BRAFMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |