Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CTSD | P07339 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1697511 | 0.83 | ALDH1A1 (0.59) | ALDH1A1CTSDMAPTLMNAHSP90AA1 | |
| SCHEMBL13948214 | 0.83 | TSHR (0.45) | ALDH1A1CTSDARMAPTLMNA | |
| Acrylic Acid SCHEMBL28586922 | 0.82 | TSHR (0.56) | ALDH1A1CTSDMAPTLMNACYP1A2 | |
| Water SCHEMBL28574745 | 0.81 | ALDH1A1 (0.58) | ALDH1A1CTSDMAPTLMNAHSP90AA1 | |
| SCHEMBL9152020 | 0.81 | ALDH1A1 (0.53) | ALDH1A1CTSDMAPTCYP1A2CYP3A4 | |
| Acrylic Acid SCHEMBL7179511 | 0.81 | ALDH1A1 (0.53) | ALDH1A1CTSDMAPTLMNACYP1A2 | |
| Acrylic Acid SCHEMBL7185194 | 0.81 | ALDH1A1 (0.53) | ALDH1A1CTSDMAPTLMNACYP1A2 | |
| Acrylic Acid SCHEMBL7179546 | 0.81 | ALDH1A1 (0.53) | ALDH1A1CTSDMAPTLMNACYP1A2 | |
| SCHEMBL28742644 | 0.79 | ALDH1A1 (0.54) | ALDH1A1CTSDMAPTLMNAHSP90AA1 | |
| SCHEMBL12112443 | 0.79 | ALDH1A1 (0.54) | ALDH1A1CTSDARMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541582-B | The MBH of alpha, beta unsaturated ketone and allyl acetic acid ester reacts | 浙江大学 | 2017-07-18 | — | — | CN | disclosed |
| EP-1378505-B1 | METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS | YAKULT HONSHA KK (JP) | 2014-11-05 | — | — | EP | disclosed |
| US-8513258-B2 | Cinnamoyl-piperazine derivatives and their use as par-1 antagonists | PIERRE FABRE MEDICAMENT (FR) | 2013-08-20 | — | — | US | disclosed |
| US-20120232097-A1 | CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR-1 ANTAGONISTS | PEREZ MICHEL (FR) | 2012-09-13 | — | — | US | disclosed |
| US-8217046-B2 | Cinnamoyl-piperazine derivatives and their use as PAR-1 antagonists | PIERRE FABRE MEDICAMENT (FR) | 2012-07-10 | — | — | US | disclosed |
| US-20090176803-A1 | CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR-1 ANTAGONISTS | PIERRE FABRE MEDICAMENT (FR) | 2009-07-09 | — | — | US | disclosed |
| EP-2041104-A1 | CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR- I ANTAGONISTS | Pierre Fabre Medicament (FR) | 2009-04-01 | — | — | EP | disclosed |
| CN-101239953-A | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | WYETH CORP (US) | 2008-08-13 | — | — | CN | disclosed |
| WO-2007147824-A1 | CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR- I ANTAGONISTS | PIERRE FABRE MEDICAMENT (FR) | 2007-12-27 | — | — | WO | disclosed |
| CN-100340562-C | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | WYETH CORP (US) | 2007-10-03 | — | — | CN | disclosed |
| CN-1681822-A | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | WYETH CORP (US) | 2005-10-12 | — | — | CN | disclosed |
| WO-2000032598-A9 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC (US) | 2000-11-30 | — | — | WO | disclosed |
| WO-2000032598-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC. (US) | 2000-06-08 | — | — | WO | disclosed |
| US-4073795-A | Synthesis of tryptophans | HOFFMANN-LA ROCHE INC. (US) | 1978-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176803-A1 | CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR-1 ANTAGONISTS | F2R, F2RL1, F2RL3 | ALDH1A1 1137/4885CTSD 346/4885AR 1230/4885 |
| US-20120232097-A1 | CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR-1 ANTAGONISTS | F2R, F2RL1, F2RL3 | ALDH1A1 1137/4885CTSD 346/4885AR 1230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.