SCHEMBL3935574

SCHEMBL3935574

Cc1cccc(C2=NCCCC2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 12/20 1.00
CHRNA3 P32297 12/20 1.00
CHRNA7 P36544 2/20 0.59
NISCH Q9Y2I1 2/20 0.47
ALDH1A1 P00352 1/20 0.46
CYP1A2 P05177 1/20 0.46
THRB P10828 1/20 0.46
CYP2C19 P33261 1/20 0.46
RAB9A P51151 2/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
MAOB P27338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6558703 0.95 CHRNB4 (0.90) CHRNB4CHRNA3CHRNA7NISCHALDH1A1
SCHEMBL18985115 0.81 CHRNB4 (0.67) CHRNB4CHRNA3CHRNA7NISCHALDH1A1
SCHEMBL24366690 0.79 CHRNB4 (0.66) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL30989312 0.79 CHRNB4 (1.00) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL24364937 0.78 CHRNB4 (0.64) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL24233984 0.77 CHRNB4 (0.64) CHRNB4CHRNA3CHRNA7NISCHALDH1A1
SCHEMBL895500 0.77 CHRNB4 (1.00) CHRNB4CHRNA3CHRNA7NISCHALDH1A1
SCHEMBL6797483 0.75 CHRNB4 (0.96) CHRNB4CHRNA3CHRNA7NISCHALDH1A1
SCHEMBL28299799 0.75 CHRNB4 (0.59) CHRNB4CHRNA3CHRNA7NISCHALDH1A1
Hydrochloric Acid SCHEMBL1418507 0.74 CHRNA7 (0.59) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2044017-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2009-04-08 EP disclosed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO disclosed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO disclosed