Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941747 | 0.89 | BRAF (0.49) | MAPTKMT2ANPC1NPSR1MEN1 | |
| SCHEMBL3934331 | 0.88 | SMN1; SMN2 (0.64) | MAPTKMT2ANPC1NPSR1MEN1 | |
| SCHEMBL2950162 | 0.83 | SMN1; SMN2 (0.53) | MAPTKMT2ANPC1NPSR1MEN1 | |
| SCHEMBL3943854 | 0.81 | BRAF (0.55) | NPC1BRAFSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL3933183 | 0.80 | SMN1; SMN2 (0.71) | MAPTKMT2ANPSR1MEN1BRAF | |
| SCHEMBL2945351 | 0.79 | LCK (0.52) | MAPTKMT2ANPC1NPSR1MEN1 | |
| SCHEMBL2947699 | 0.79 | SMN1; SMN2 (0.50) | MAPTKMT2ANPC1NPSR1MEN1 | |
| SCHEMBL7767712 | 0.78 | MAPT (0.64) | MAPTKMT2ANPC1NPSR1MEN1 | |
| SCHEMBL30354862 | 0.77 | KMT2A (0.54) | MAPTKMT2ANPC1NPSR1MEN1 | |
| SCHEMBL4175332 | 0.77 | BRAF (0.67) | MAPTKMT2ANPC1MEN1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |