Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.65 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | BRAF | P15056 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26758011 | 0.88 | SMN1; SMN2 (0.74) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL2950162 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AMEN1MAPTCYP1A2 | |
| SCHEMBL3937705 | 0.85 | SMN1; SMN2 (0.82) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL3936626 | 0.85 | SMN1; SMN2 (0.71) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL3934052 | 0.85 | GAA (0.69) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL3935767 | 0.80 | MAPT (0.57) | SMN1; SMN2KMT2AMEN1BRAFMAPT | |
| SCHEMBL7128348 | 0.80 | SMN1; SMN2 (0.72) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL3934041 | 0.80 | BRAF (0.63) | CYP11B2CYP11B1KMT2AMEN1BRAF | |
| SCHEMBL13161982 | 0.80 | BRAF (0.74) | CYP11B2CYP11B1BRAFMAPTPOLB | |
| SCHEMBL7371634 | 0.79 | CYP11B1 (1.00) | SMN1; SMN2CYP11B2CYP11B1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |