Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.86 |
| ▸ | CSF1R | P07333 | 4/20 | 0.86 |
| ▸ | KIT | P10721 | 2/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.74 |
| ▸ | KDR | P35968 | 1/20 | 0.74 |
| ▸ | LCK | P06239 | 3/20 | 0.70 |
| ▸ | ABL1 | P00519 | 1/20 | 0.70 |
| ▸ | SRC | P12931 | 1/20 | 0.70 |
| ▸ | BTK | Q06187 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1276318 | 0.93 | BRAF (1.00) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3934255 | 0.92 | BRAF (0.83) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3934672 | 0.87 | BRAF (1.00) | BRAFCSF1R | |
| SCHEMBL3943781 | 0.87 | BRAF (0.82) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3937762 | 0.87 | BRAF (0.82) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3932667 | 0.85 | BRAF (0.73) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3942520 | 0.85 | BRAF (1.00) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL1276903 | 0.85 | BRAF (1.00) | BRAFCSF1RBTK | |
| SCHEMBL3937779 | 0.85 | BRAF (1.00) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3935822 | 0.85 | BRAF (0.72) | BRAFCSF1RKITMAPK14KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |