Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12321230 | 0.92 | CTSK (0.59) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL3544236 | 0.92 | CTSK (0.59) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL3942865 | 0.92 | CTSK (0.59) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL342772 | 0.84 | CA1 (0.62) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL342773 | 0.84 | CA1 (0.62) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL20184622 | 0.84 | CA1 (0.62) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL3965693 | 0.83 | CTSK (0.55) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL26091580 | 0.83 | CA1 (0.57) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL13102166 | 0.81 | CTSK (0.57) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL13102176 | 0.81 | CTSK (0.57) | CTSKCA1CA2HSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |