Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 18/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | MTOR | P42345 | 2/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927820 | 0.90 | ATR (0.46) | ATRPIK3CAMTORPIK3CD | |
| SCHEMBL3924871 | 0.89 | PIK3CA (0.54) | ATRPIK3CAMTORPIK3CD | |
| SCHEMBL3929189 | 0.88 | ATR (0.44) | ATRPIK3CAMTORPIK3CD | |
| SCHEMBL3934684 | 0.86 | PIK3CA (0.51) | ATRPIK3CAMTORPIK3CD | |
| SCHEMBL3925867 | 0.85 | ATR (0.69) | ATRPIK3CAMTORPIK3CD | |
| SCHEMBL3933002 | 0.83 | PIK3CA (0.71) | ATRPIK3CAMTORPIK3CD | |
| SCHEMBL3929791 | 0.82 | PIK3CA (0.65) | ATRPIK3CAMTORPIK3CD | |
| SCHEMBL4207747 | 0.82 | ATR (0.62) | ATRPIK3CAMTORPIK3CD | |
| SCHEMBL3929792 | 0.82 | ATR (0.65) | ATRPIK3CAMTORPIK3CD | |
| SCHEMBL3924449 | 0.82 | ATR (0.64) | ATRPIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074118-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | AstraZeneca AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |