Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIG1 | P18858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CXCR5 | P32302 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28299986 | 0.93 | KDM4E (0.56) | LIG1KDM4EPOLBADRB2ADRB1 | |
| SCHEMBL10389427 | 0.91 | CYP3A4 (0.50) | LIG1KDM4EPOLBADRB2ADRB1 | |
| SCHEMBL15813878 | 0.88 | LIG1 (0.46) | LIG1KDM4EPOLBADRB2ADRB1 | |
| SCHEMBL30195826 | 0.86 | LIG1 (0.68) | LIG1KDM4EADRB2ADRB1ADRB3 | |
| SCHEMBL385145 | 0.86 | LIG1 (0.68) | LIG1KDM4EADRB2ADRB1ADRB3 | |
| SCHEMBL11239113 | 0.85 | LIG1 (0.55) | LIG1KDM4EPOLBADRB2ADRB1 | |
| SCHEMBL2431626 | 0.85 | LIG1 (0.55) | LIG1KDM4EPOLBADRB2ADRB1 | |
| SCHEMBL3944765 | 0.85 | LIG1 (0.54) | LIG1KDM4EPOLBADRB2ADRB1 | |
| SCHEMBL20415950 | 0.84 | BLM (0.45) | LIG1KDM4EPOLBADRB2ADRB1 | |
| SCHEMBL20471918 | 0.84 | LIG1 (0.47) | LIG1KDM4EPOLBADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | THE UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-12-31 | — | — | US | disclosed |
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | THE UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-12-31 | — | — | US | disclosed |
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | THE UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-12-31 | — | — | US | disclosed |
| EP-2046768-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | Kudos Pharmaceuticals Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008009934-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008009934-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | XRN2, ASNS, CYP2B6 | LIG1 499/4885KDM4E 2800/4885POLB 2607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.