Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1022867 | 0.82 | MAPT (0.55) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL14658935 | 0.81 | MAPT (0.64) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL30672834 | 0.81 | MAPT (0.64) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL7751102 | 0.80 | MAPT (0.59) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL13602607 | 0.79 | KMT2A (0.60) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL30189760 | 0.78 | CYP2C19 (0.44) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL14658583 | 0.78 | CYP2C19 (0.44) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL29481726 | 0.78 | GABRA5 (0.44) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL16973106 | 0.78 | GABRA5 (0.44) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL15205661 | 0.78 | ATM (0.43) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| EP-1831198-A1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067445-A2 | CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |
| WO-2006067446-A1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |