Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 18/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | MTOR | P42345 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | TAF1 | P21675 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200627 | 1.00 | ATR (0.42) | ATRPIK3CAMTORKCNH2NSD2 | |
| SCHEMBL4204399 | 0.87 | ATR (0.52) | ATRPIK3CAMTORKCNH2ATRIP | |
| SCHEMBL4194683 | 0.84 | ATR (0.47) | ATRPIK3CAMTORKCNH2ATRIP | |
| SCHEMBL4208726 | 0.83 | ATR (0.50) | ATRPIK3CAMTORKCNH2ATRIP | |
| SCHEMBL4207261 | 0.83 | ATR (0.49) | ATRPIK3CAMTORKCNH2ATRIP | |
| SCHEMBL4198871 | 0.83 | ATR (0.49) | ATRPIK3CAMTORKCNH2ATRIP | |
| SCHEMBL4207774 | 0.82 | ATR (0.47) | ATRPIK3CAMTORKCNH2ATRIP | |
| SCHEMBL4168167 | 0.82 | ATR (0.47) | ATRPIK3CAMTORKCNH2ATRIP | |
| SCHEMBL4195327 | 0.81 | MTOR (0.42) | ATRPIK3CAMTORKCNH2ATRIP | |
| SCHEMBL3934398 | 0.81 | MTOR (0.42) | ATRPIK3CAMTORKCNH2ATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074118-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | AstraZeneca AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |