Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 18/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.39 |
| ▸ | TAF1 | P21675 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4207774 | 1.00 | ATR (0.47) | ATRPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL4207176 | 0.88 | ATR (0.52) | ATRPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL4198487 | 0.87 | ATR (0.54) | ATRPIK3CAMTORATRIPTAF1 | |
| SCHEMBL4206721 | 0.85 | ATR (0.53) | ATRPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL4210192 | 0.85 | ATR (0.49) | ATRPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL4196995 | 0.85 | ATR (0.49) | ATRPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL4205311 | 0.85 | MTOR (0.53) | ATRPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL4167867 | 0.85 | MTOR (0.53) | ATRPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL3928752 | 0.84 | PIK3CA (0.45) | ATRPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL8098740 | 0.83 | MTOR (0.53) | ATRPIK3CAMTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074118-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | AstraZeneca AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |