Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 7/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941819 | 0.87 | BRAF (0.83) | BRAFCYP2C9CSF1RKITKDR | |
| SCHEMBL3937355 | 0.80 | BRAF (0.49) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3934840 | 0.79 | BRAF (0.78) | BRAFCYP2C9CSF1RRAF1MAPK14 | |
| SCHEMBL3929892 | 0.78 | BRAF (1.00) | BRAFCYP2C9KITKDRMAPK14 | |
| SCHEMBL3933304 | 0.77 | MAPK14 (0.72) | BRAFCYP2C9CSF1RKITKDR | |
| SCHEMBL3944406 | 0.76 | BRAF (0.69) | BRAFCYP2C9CSF1RMAPK14 | |
| SCHEMBL3939108 | 0.76 | BRAF (0.78) | BRAFCYP2C9CSF1R | |
| SCHEMBL3944021 | 0.76 | BRAF (0.82) | BRAFCYP2C9CSF1RMAPK14 | |
| SCHEMBL3936862 | 0.76 | BRAF (0.57) | BRAFCYP2C9RAF1 | |
| SCHEMBL3934910 | 0.74 | BRAF (0.81) | BRAFCYP2C9CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |