Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 8/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 4/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPRA | P18433 | 1/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | PTPRE | P23469 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17134758 | 0.87 | RAB9A (0.49) | IDO1DHODHALDH1A1HPGDRAB9A | |
| SCHEMBL24550893 | 0.85 | CLCN2 (0.48) | IDO1DHODHCLCN2 | |
| SCHEMBL30824174 | 0.85 | CLCN2 (0.48) | IDO1DHODHCLCN2 | |
| SCHEMBL12129602 | 0.85 | MAP2K1 (0.56) | IDO1MAP2K1MAP2K2 | |
| SCHEMBL3873690 | 0.84 | TP53 (0.49) | IDO1MAP2K1MAP2K2MEN1KMT2A | |
| SCHEMBL17688897 | 0.83 | AKR1C3 (0.48) | DHODHHPGDMEN1USP2KMT2A | |
| SCHEMBL3880926 | 0.82 | IDO1 (0.58) | IDO1MAP2K1MAP2K2PTPRCPTPN2 | |
| SCHEMBL5680871 | 0.80 | IDO1 (0.61) | IDO1MAP2K1MAP2K2ALDH1A1RAB9A | |
| SCHEMBL17134862 | 0.79 | CLCN2 (0.52) | DHODHRAB9ASMN1; SMN2CLCN2MEN1 | |
| SCHEMBL5678007 | 0.79 | IDO1 (0.70) | IDO1MAP2K1MAP2K2PTPRCPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828184-B1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | MERCK SERONO SA (CH) | 2009-09-16 | — | — | EP | disclosed |
| US-20070299103-A1 | [1,2,4]Triazolo[4,3-A]Pyridine Derivatives for the Treatment of Hyperproliferative Diseases | MERCK SERONO SA (CH) | 2007-12-27 | — | — | US | disclosed |
| EP-1828184-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006058752-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | LABORATOIRES SERONO S.A. (CH) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299103-A1 | [1,2,4]Triazolo[4,3-A]Pyridine Derivatives for the Treatment of Hyperproliferative Diseases | CDK4, CDK3, BRAF | IDO1 1077/4885MAP2K1 114/4885MAP2K2 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.