Candesartan

Candesartan

SCHEMBL3938

CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AGTR1

The experimentally established mechanism targets of Candesartan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AGTR1 known ✓ P30556 2/20 0.73
ABCB11 O95342 1/20 0.73
EGFR P00533 1/20 0.73
ERBB2 P04626 1/20 0.73
CYP3A4 P08684 1/20 0.73
ADORA3 P0DMS8 1/20 0.73
CYP2C9 P11712 1/20 0.73
ADRB3 P13945 1/20 0.73
ADRA2B P18089 1/20 0.73
SLC6A2 P23975 1/20 0.73
TBXAS1 P24557 1/20 0.73
HTR2C P28335 1/20 0.73
PPARG P37231 1/20 0.73
HTR2B P41595 1/20 0.73
AGTR2 P50052 1/20 0.73
PDE3A Q14432 1/20 0.73
LTB4R2 Q9NPC1 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Candesartan SCHEMBL29508236 1.00 AGTR1 (0.73) AGTR1ABCB11EGFRERBB2CYP3A4
Candesartan SCHEMBL29682351 1.00 AGTR1 (0.73) AGTR1ABCB11EGFRERBB2CYP3A4
Candesartan SCHEMBL19357208 1.00 AGTR1 (0.73) AGTR1ABCB11EGFRERBB2CYP3A4
Candesartan SCHEMBL16237819 0.99 AGTR1 (0.72) AGTR1ABCB11EGFRERBB2CYP3A4
Candesartan SCHEMBL7292788 0.99 AGTR1 (0.72) AGTR1ABCB11EGFRERBB2CYP3A4
Candesartan SCHEMBL27825805 0.99 AGTR1 (0.72) AGTR1ABCB11EGFRERBB2CYP3A4
Candesartan SCHEMBL28786878 0.99 AGTR1 (0.72) AGTR1ABCB11EGFRERBB2CYP3A4
Candesartan SCHEMBL5507160 0.99 AGTR1 (0.72) AGTR1ABCB11EGFRERBB2CYP3A4
Candesartan SCHEMBL27825863 0.99 AGTR1 (0.72) AGTR1ABCB11EGFRERBB2CYP3A4
Candesartan SCHEMBL27825804 0.99 AGTR1 (0.72) AGTR1ABCB11EGFRERBB2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 29844 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747238-A1 PROCESS FOR PREPARING INTERMEDIATES OF SARTAN ACTIVE COMPOUNDS Sanofi (FR) 2026-05-27 EP claimed
US-20260124180-A1 METHOD OF TREATING AFFECTIVE DISORDERS AND PERSONALITY DISORDERS HB BIOTECH, INC. (US) 2026-05-07 US claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
EP-4736841-A1 A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT IQ medical GmbH (DE) 2026-05-06 EP claimed
EP-3934654-B1 ISTAROXIME OR ITS METABOLITE PST-3093 FOR USE AS INTRAVENOUS FORMULATION FOR THE TREATMENT OF ACUTE HEART FAILURE (AHF) WINDTREE THERAPEUTICS INC (US) 2026-04-29 EP claimed
EP-4724060-A1 FORMULATIONS AND METHODS FOR TREATING NEUROPSYCHIATRIC DISORDERS HB Biotech, Inc. (US) 2026-04-15 EP claimed
US-20260097039-A1 METHODS FOR TREATING A FATTY LIVER DISEASE MADRIGAL PHARMACEUTICALS INC (US) 2026-04-09 US claimed
US-12594278-B2 Method for treatment of muscular dystrophy CHILDREN'S NATIONAL MEDICAL CENTER (US) 2026-04-07 US claimed
EP-4215194-B1 COMBINATION THERAPY OF AT1 R BLOCKER AND CCR2 INHIBITOR FOR THE TREATMENT, AMELIORATION OR PREVENTION OF A KIDNEY DISEASE DIMERIX BIOSCIENCE PTY LTD (AU) 2026-03-25 EP claimed
US-12582601-B2 Orodispersible powder composition BIOPHARMA SYNERGIES, S.L. (ES) 2026-03-24 US claimed
WO-1996040258-A2 SPIRONOLACTONE AND ANGIOTENSIN II ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE G.D. SEARLE & CO. (US) 1996-12-19 WO claimed
WO-1996040257-A1 EPOXY-STEROIDAL ALDOSTERONE ANTAGONIST AND ANGIOTENSIN II ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE G.D. SEARLE & CO. (US) 1996-12-19 WO claimed
EP-0720982-A1 Benzimidazole derivatives, their production and use and use as angiotensin II antagonists TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-07-10 EP claimed
WO-1995001176-A1 USE OF AN ANGIOTENSIN II ANTAGONIST AS AN OCULAR HYPOTENSIVE AGENT SENJU PHARMACEUTICAL CO., LTD. (JP) 1995-01-12 WO claimed
EP-0631780-A1 Use of an angiotensin II antagonist as an ocular hypotensive agent TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-01-04 EP claimed
EP-0628313-A1 Combination of benzimidazoles having angiotensin-II antagonistic activity with dinretics or calcium antagonists TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-12-14 EP claimed
EP-0622077-A1 Angiotensin II antagonists as a prophylactic or therapeutic drug for renal diseases TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-11-02 EP claimed
EP-0612523-A1 Vascular hypertrophy suppressor TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-08-31 EP claimed
EP-0612524-A1 Angiotensin II antagonists for the treatment of viral diseases TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-08-31 EP claimed
EP-0459136-A1 Benzimidazole derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1991-12-04 EP claimed