Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 17/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3938546 | 0.91 | CCR5 (0.58) | CCR5PTGDR2KDM4EALDH1A1 | |
| SCHEMBL3928082 | 0.90 | CCR5 (0.52) | CCR5PTGDR2KDM4EALDH1A1 | |
| SCHEMBL3927273 | 0.90 | CCR5 (0.57) | CCR5PTGDR2 | |
| SCHEMBL3931490 | 0.89 | CCR5 (0.51) | CCR5PTGDR2 | |
| SCHEMBL3928710 | 0.89 | VEGFA (0.55) | CCR5PTGDR2 | |
| SCHEMBL3933237 | 0.89 | CCR5 (0.56) | CCR5PTGDR2 | |
| SCHEMBL3928937 | 0.88 | PTGDR2 (0.57) | CCR5PTGDR2 | |
| SCHEMBL3928637 | 0.86 | PTGDR2 (0.59) | CCR5PTGDR2KDM4EALDH1A1 | |
| SCHEMBL3928824 | 0.86 | PTGDR2 (0.59) | CCR5PTGDR2KDM4EALDH1A1 | |
| SCHEMBL3939170 | 0.85 | PTGDR2 (0.61) | CCR5PTGDR2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |