Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.46 |
| ▸ | CDK1 | P06493 | 6/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953763 | 0.92 | CDK2 (0.51) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL3938476 | 0.85 | CDK2 (0.46) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL8296015 | 0.83 | CDK2 (0.64) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL8221113 | 0.83 | CDK2 (0.64) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL8214922 | 0.82 | CDK2 (0.64) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL4288778 | 0.82 | CDK2 (0.61) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL3942467 | 0.82 | CDK2 (0.48) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL8261124 | 0.81 | CDK2 (0.52) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL1286713 | 0.81 | CDK2 (0.63) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL8224826 | 0.81 | CDK2 (0.51) | CDK2CCNA2CDK1CCNB1CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046327-A1 | MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS | Astex Therapeutics Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| EP-2046330-A2 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008009954-A1 | MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008007122-A2 | COMBINATIONS OF PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDKS AND GSK'S | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |