Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.48 |
| ▸ | CDK1 | P06493 | 9/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | FES | P07332 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL955039 | 0.90 | MEN1 (0.49) | CDK2CDK1CCNA2CCNB1CCNA1 | |
| SCHEMBL3939511 | 0.87 | LMNA (0.48) | MEN1KMT2AHDAC1HTTRAB9A | |
| SCHEMBL4450271 | 0.86 | HDAC1 (0.53) | CDK2CCNA2MEN1KMT2APOLB | |
| SCHEMBL3938477 | 0.82 | CDK2 (0.46) | CDK2CDK1CCNA2CCNB1CCNA1 | |
| SCHEMBL956928 | 0.82 | CDK1 (0.60) | CDK2CDK1CCNA2CCNB1CCNA1 | |
| SCHEMBL1645592 | 0.82 | JAK2 (0.52) | CDK2CCNA2MEN1KMT2APOLB | |
| SCHEMBL8219373 | 0.81 | MEN1 (0.48) | CDK2CDK1CCNA2CCNB1CCNA1 | |
| SCHEMBL3937911 | 0.81 | KMT2A (0.43) | MEN1KMT2APOLBRAB9AMAPT | |
| SCHEMBL3587804 | 0.80 | MEN1 (0.47) | CDK2CDK1CCNA2CCNB1CCNA1 | |
| SCHEMBL3936265 | 0.80 | KMT2A (0.47) | MEN1KMT2APOLBRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049106-A2 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-04-22 | — | — | EP | disclosed |
| EP-2046330-A2 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008007122-A2 | COMBINATIONS OF PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDKS AND GSK'S | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007113-A2 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |