Gossypol

Gossypol

SCHEMBL3939

Cc1cc2c(C(C)C)c(O)c(O)c(C=O)c2c(O)c1-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 12/20 1.00
BCL2 P10415 11/20 1.00
AKR1B1 P15121 5/20 1.00
KDM4E B2RXH2 2/20 1.00
MEN1 O00255 2/20 1.00
NPC1 O15118 2/20 1.00
USP2 O75604 2/20 1.00
ALDH1A1 P00352 2/20 1.00
LMNA P02545 2/20 1.00
POLB P06746 2/20 1.00
GAA P10253 2/20 1.00
MAPT P10636 2/20 1.00
THRB P10828 2/20 1.00
HPGD P15428 2/20 1.00
ALOX12 P18054 2/20 1.00
MAPK1 P28482 2/20 1.00
BLM P54132 2/20 1.00
KMT2A Q03164 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
NPSR1 Q6W5P4 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gossypol SCHEMBL30260519 1.00 MCL1 (1.00) MCL1BCL2AKR1B1KDM4EMEN1
Gossypol SCHEMBL29798874 1.00 MCL1 (1.00) MCL1BCL2AKR1B1KDM4EMEN1
Gossypol SCHEMBL9738017 1.00 MCL1 (1.00) MCL1BCL2AKR1B1KDM4EMEN1
Gossypol SCHEMBL29355719 1.00 MCL1 (1.00) MCL1BCL2AKR1B1KDM4EMEN1
Gossypol SCHEMBL23014699 0.98 MCL1 (0.97) MCL1BCL2AKR1B1KDM4EMEN1
Gossypol SCHEMBL27542391 0.98 MCL1 (0.97) MCL1BCL2AKR1B1KDM4EMEN1
Gossypol SCHEMBL27755741 0.98 MCL1 (0.97) MCL1BCL2AKR1B1KDM4EMEN1
Gossypol SCHEMBL28855396 0.98 MCL1 (0.97) MCL1BCL2AKR1B1KDM4EMEN1
Gossypol SCHEMBL28166062 0.98 MCL1 (0.97) MCL1BCL2AKR1B1KDM4EMEN1
Gossypol SCHEMBL11156705 0.97 MCL1 (0.94) MCL1BCL2AKR1B1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 16182 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118001240-B Podophyllotoxin-9-fluorenylmethanol small molecule prodrug nanoparticle and preparation method and application thereof SHENYANG PHARMACEUTICAL UNIVERSITY (CN) 2026-05-26 CN claimed
CN-122081099-A Free gossypol degrading bacterium YJQ-1 and application thereof 2026-05-26 CN claimed
CN-122036558-A Gossypol derivative, preparation method thereof and application thereof in preparation of coronavirus 3CL protease inhibitor 陕西盘龙药业集团股份有限公司 2026-05-15 CN claimed
CN-122030519-A Yeast culture-based functional feed formula for pseudobagrus ussuriensis and application of functional feed formula 东北农业大学 2026-05-15 CN claimed
CN-122012510-A Gossypol specific nucleic acid aptamer and preparation method and application thereof 新疆大学 2026-05-12 CN claimed
CN-122022567-A Non-grain type protein source feed quality safety evaluation method 宁夏大学 2026-05-12 CN claimed
CN-122028938-A Pharmaceutical combination comprising an anti-CD 37 antibody maytansinoid conjugate and a BCL2 inhibitor or PI3K inhibitor 德彪药业国际股份公司 2026-05-12 CN claimed
US-20260124242-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND THERAPEUTIC USES THEREOF IOVANCE BIOTHERAPEUTICS INC (US) 2026-05-07 US claimed
US-20260107893-A1 METHOD FOR EVALUATING INFLUENCE BY GENE-EDITED LOW-GOSSYPOL COTTON ON APHIS GOSSYPII INSTITUTE OF COTTON RESEARCH OF CAAS (CN) 2026-04-23 US claimed
EP-4727933-A1 COMBINATION THERAPY METHODS FOR TREATING TP53-Y220C MUTANT AND TP53 WILDTYPE LEUKEMIAS Board of Regents, The University of Texas System (US) 2026-04-22 EP claimed
EP-0127677-A1 READILY-ABSORPABLE FATTY ACID EMULSIONS. HAFSTEN RAYMOND J JR (US) 1984-12-12 EP claimed
WO-1984002271-A1 READILY-ABSORPABLE FATTY ACID EMULSIONS HAFSTEN RAYMOND J JR (US) 1984-06-21 WO claimed
US-4381298-A Oral male contraceptive composition COULSON PATRICIA B 1983-04-26 US claimed
US-4359417-A Process for extracting oleaginous seed materials particularly cottonseed with aqueous alcohol DRAVO CORPORATION (US) 1982-11-16 US claimed
US-4297341-A GOSSYPOL-MODIFIED POLYVINYLPYRROLIDONE; CONTRACEPTIVES; UROGENITAL SYSTEMS UNIVERSITY OF ILLINOIS FOUNDATION (US) 1981-10-27 US claimed
US-4279811-A Treatment of cottonseed meals followed by extraction with certain solvents to remove gossypol THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1981-07-21 US claimed
US-4201709-A FLAKING, SOLVENT EXTRACTION THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1980-05-06 US claimed
US-4139646-A TO SEPARATE INTACT THE PIGMENT GLANDS AND TO PRODUCE A PROTEIN-RICH FLOUR CONCENTRATE Stewart, Charles L. (US) 1979-02-13 US claimed
US-4084007-A Method of producing edible meal from cottonseed CARPAT INTERNATIONAL INC. (US) 1978-04-11 US claimed
US-3953260-A HYDROXY TERMINATED POLYBUTADINE THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1976-04-27 US claimed