Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 4/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | JAK3 | P52333 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294568 | 0.87 | AURKA (0.56) | AURKAAURKB | |
| SCHEMBL3005925 | 0.83 | IGF1R (0.59) | IGF1R | |
| SCHEMBL3936381 | 0.82 | TDP1 (0.51) | NTRK1TDP1MAPTLMNACYP1A2 | |
| SCHEMBL3939475 | 0.79 | PAK4 (0.56) | NTRK1AURKAAURKBJAK2JAK3 | |
| SCHEMBL10312104 | 0.78 | NTRK1 (0.54) | NTRK1AURKAAURKBTDP1JAK2 | |
| SCHEMBL219543 | 0.78 | JAK3 (0.59) | NTRK1AURKAAURKBJAK2JAK3 | |
| SCHEMBL10312145 | 0.78 | AURKA (0.56) | NTRK1AURKAAURKBJAK2JAK3 | |
| SCHEMBL13943376 | 0.76 | JAK3 (0.76) | NTRK1AURKAAURKBJAK2JAK3 | |
| SCHEMBL23321312 | 0.75 | LMNA (0.82) | TDP1MAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL10312220 | 0.74 | NTRK1 (0.50) | NTRK1AURKAAURKBJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |