Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 13/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755338 | 0.87 | KCNA5 (0.58) | KCNA5SCN9ASCN5ATDP1KCNH2 | |
| SCHEMBL3745337 | 0.86 | KCNA5 (0.56) | KCNA5SCN9ASCN5ATDP1KCNH2 | |
| SCHEMBL3762666 | 0.86 | KCNA5 (0.56) | KCNA5SCN9ASCN5ATDP1KCNH2 | |
| SCHEMBL3941288 | 0.83 | SCN9A (0.54) | KCNA5SCN9ASCN5ATDP1KCNH2 | |
| SCHEMBL3758283 | 0.82 | KCNA5 (0.59) | KCNA5SCN9ASCN5ATDP1KCNH2 | |
| SCHEMBL3747617 | 0.82 | SCN9A (0.53) | KCNA5SCN9ASCN5ATDP1KCNH2 | |
| SCHEMBL3751702 | 0.81 | KCNA5 (0.69) | KCNA5SCN9ASCN5ATDP1KCNH2 | |
| SCHEMBL3942460 | 0.80 | SCN9A (0.59) | KCNA5SCN9ASCN5AKCNH2PRMT5 | |
| SCHEMBL3942929 | 0.79 | TDP1 (0.45) | KCNA5SCN9ASCN5ATDP1KCNH2 | |
| SCHEMBL3755928 | 0.79 | SCN9A (0.53) | KCNA5SCN9ASCN5AKCNH2PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |