Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756367 | 0.83 | KCNA5 (0.51) | TDP1KCNA5ALDH1A1SCN9ASCN5A | |
| SCHEMBL3750868 | 0.83 | KCNA5 (0.56) | TDP1KCNA5ALDH1A1SCN9ASCN5A | |
| SCHEMBL3756691 | 0.80 | KCNA5 (0.66) | TDP1KCNA5ALDH1A1SCN9ASCN5A | |
| SCHEMBL3939936 | 0.79 | KCNA5 (0.52) | TDP1KCNA5SCN9ASCN5AKCNH2 | |
| SCHEMBL13568314 | 0.76 | SCN9A (0.69) | KCNA5SCN9ASCN5AKCNH2 | |
| SCHEMBL3946131 | 0.70 | KCNA5 (0.69) | TDP1KCNA5ALDH1A1SCN9ASCN5A | |
| SCHEMBL3757961 | 0.69 | KCNA5 (0.61) | TDP1KCNA5ALDH1A1SCN9ASCN5A | |
| SCHEMBL3750023 | 0.69 | KCNA5 (0.74) | TDP1KCNA5SCN9ASCN5AKCNH2 | |
| SCHEMBL3755441 | 0.69 | KCNA5 (0.59) | TDP1KCNA5ALDH1A1SCN9ASCN5A | |
| SCHEMBL4347580 | 0.69 | EPHX2 (0.43) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |