Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14397784 | 0.92 | ALDH1A1 (0.63) | ALDH1A1KMT2AAKR1C3TRPA1MAPT | |
| SCHEMBL27580953 | 0.89 | ALDH1A1 (0.59) | ALDH1A1KMT2AAKR1C3TRPA1MAPT | |
| SCHEMBL4678464 | 0.88 | ALDH1A1 (0.67) | ALDH1A1KMT2AAKR1C3MAPTGAA | |
| SCHEMBL83108 | 0.86 | ALDH1A1 (0.65) | ALDH1A1KMT2AAKR1C3MAPTGAA | |
| SCHEMBL819016 | 0.86 | MAPT (0.66) | ALDH1A1KMT2AMAPTMEN1PKM | |
| SCHEMBL10725281 | 0.86 | ALDH1A1 (0.56) | ALDH1A1KMT2AAKR1C3TRPA1MAPT | |
| SCHEMBL12683508 | 0.85 | ALDH1A1 (0.55) | ALDH1A1KMT2AAKR1C3TRPA1MAPT | |
| SCHEMBL28228800 | 0.85 | ALDH1A1 (0.63) | ALDH1A1KMT2AAKR1C3MAPTGAA | |
| SCHEMBL2047090 | 0.85 | CYP2C19 (0.66) | ALDH1A1KMT2AAKR1C3MAPTBDKRB1 | |
| SCHEMBL8174226 | 0.83 | KMT2A (0.62) | ALDH1A1KMT2AAKR1C3MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218004-B1 | 5-METHYL INDIRUBIN FOR USE IN THE TREATMENT OF HUMAN SOLID TUMORS | FIEBIG HEINZ HERBERT (DE) | 2009-04-08 | — | — | EP | disclosed |
| US-6664285-B1 | Administering for treatment of human solid tumors and metastasis thereof | EISENBRAND GERHARD (DE) | 2003-12-16 | — | — | US | disclosed |