Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT7 | O95251 | 13/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 13/20 | 0.47 |
| ▸ | KAT6B | Q8WYB5 | 8/20 | 0.47 |
| ▸ | KAT5 | Q92993 | 5/20 | 0.47 |
| ▸ | KAT8 | Q9H7Z6 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29008820 | 0.80 | KDM4E (0.52) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL27760047 | 0.79 | KDM4E (0.49) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL28557215 | 0.79 | MAPT (0.46) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL27766479 | 0.78 | POLB (0.41) | KAT7KAT6ALMNAHTTALDH1A1 | |
| SCHEMBL28557207 | 0.74 | KAT7 (0.47) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL31516718 | 0.72 | KAT7 (0.51) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL31516659 | 0.72 | KAT7 (0.47) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL4796562 | 0.72 | GAA (0.48) | KAT7KAT6ALMNAMAPTHTT | |
| SCHEMBL3319825 | 0.71 | MAPT (0.55) | KAT7KAT6AMAPTHTTALDH1A1 | |
| SCHEMBL22317331 | 0.71 | HTT (0.55) | KAT7KAT6ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108020-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | disclosed |
| EP-2108019-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | disclosed |
| WO-2008094602-A2 | 1-H-PYRAZOLO (3,4B) PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008094575-A2 | 1-H-PYRAZOLO(3,4B)PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | disclosed |