Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 17/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.58 |
| ▸ | SCN5A | Q14524 | 12/20 | 0.58 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755957 | 0.84 | SCN9A (0.61) | SCN9AKCNH2SCN5AKCNQ2KCNA5 | |
| SCHEMBL3756567 | 0.83 | SCN9A (0.76) | SCN9AKCNH2SCN5AKCNQ2KCNA5 | |
| SCHEMBL3756103 | 0.80 | SCN9A (0.62) | SCN9AKCNH2SCN5AKCNQ2KCNA5 | |
| SCHEMBL13568403 | 0.74 | SCN9A (1.00) | SCN9AKCNH2SCN5AKCNQ2KCNA5 | |
| SCHEMBL3888988 | 0.73 | SCN9A (0.58) | SCN9AKCNH2SCN5AKCNQ2KCNA5 | |
| SCHEMBL3750835 | 0.73 | MDM2 (0.57) | SCN9AKCNH2SCN5AKCNA5 | |
| SCHEMBL3750814 | 0.73 | SCN9A (0.66) | SCN9AKCNH2SCN5AKCNQ2KCNA5 | |
| SCHEMBL3950452 | 0.71 | SCN9A (0.67) | SCN9AKCNH2SCN5AKCNQ2KCNA5 | |
| SCHEMBL7957008 | 0.71 | ADRA1D (0.62) | CHRM5ADRA1DADRA1AADRA1B | |
| SCHEMBL3753489 | 0.71 | SCN9A (0.67) | SCN9AKCNH2SCN5AKCNQ2KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |