Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | DPP4 | P27487 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099213 | 0.95 | SMN1; SMN2 (0.57) | SMN1; SMN2POLBDPP4MAPTRAB9A | |
| SCHEMBL6087660 | 0.91 | DPP4 (0.57) | SMN1; SMN2POLBDPP4MAPTRAB9A | |
| SCHEMBL1146057 | 0.89 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBDPP4MAPTRAB9A | |
| SCHEMBL30014816 | 0.89 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBDPP4MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL6638580 | 0.88 | SMN1; SMN2 (0.58) | SMN1; SMN2POLBDPP4MAPTRAB9A | |
| SCHEMBL10428305 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBDPP4MAPTRAB9A | |
| SCHEMBL10514450 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBDPP4MAPTRAB9A | |
| SCHEMBL10512551 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBDPP4MAPTRAB9A | |
| SCHEMBL10428096 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBDPP4MAPTRAB9A | |
| SCHEMBL5653220 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBDPP4MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |
| WO-1999021870-A1 | ERYTHROMYCIN A 11, 12-CARBAMATE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1999-05-06 | — | — | WO | disclosed |