Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10428096 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2HCAR3POLBMAPTRAB9A | |
| SCHEMBL10514450 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2HCAR3POLBMAPTRAB9A | |
| SCHEMBL31629193 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2HCAR3POLBMAPTRAB9A | |
| SCHEMBL10512551 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2HCAR3POLBMAPTRAB9A | |
| SCHEMBL10428227 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2HCAR3POLBMAPTRAB9A | |
| SCHEMBL10428305 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2HCAR3POLBMAPTRAB9A | |
| SCHEMBL5650522 | 0.88 | SMN1; SMN2 (0.60) | SMN1; SMN2HCAR3POLBMAPTRAB9A | |
| SCHEMBL3941650 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBMAPTRAB9ANPC1 | |
| SCHEMBL8365566 | 0.82 | DPP4 (0.58) | SMN1; SMN2POLBMAPTRAB9ANPC1 | |
| SCHEMBL6657510 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2POLBMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| CN-1391563-A | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |
| US-4001254-A | ISOTHIOCYANOPYRIDINE DERIVATIVES | CIBA-GEIGY CORPORATION (US) | 1977-01-04 | — | — | US | disclosed |