Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12130564 | 0.94 | DPP4 (0.57) | DPP4HRH3ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL491927 | 0.94 | DPP4 (0.57) | DPP4HRH3ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3350836 | 0.92 | DPP4 (0.63) | DPP4HRH3ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3185546 | 0.89 | MAPT (0.61) | DPP4ALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL5099448 | 0.89 | DPP4 (0.66) | DPP4HRH3ALDH1A1POLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7856206 | 0.88 | DPP4 (0.65) | DPP4HRH3ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6152689 | 0.81 | PKM (0.56) | DPP4ALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL3995356 | 0.80 | HRH3 (0.57) | HRH3ALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL5099785 | 0.78 | DPP4 (0.56) | DPP4ALDH1A1POLBSMN1; SMN2DPP7 | |
| SCHEMBL5099213 | 0.78 | SMN1; SMN2 (0.57) | DPP4ALDH1A1POLBSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |