Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.64 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176638 | 0.96 | TRPA1 (0.70) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6176643 | 0.96 | TRPA1 (0.70) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6178957 | 0.88 | TRPA1 (0.56) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6178952 | 0.88 | TRPA1 (0.56) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6179258 | 0.84 | PSEN1 (0.67) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6179250 | 0.84 | PSEN1 (0.67) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6178648 | 0.84 | TRPA1 (0.62) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6178548 | 0.84 | TRPA1 (0.70) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6178544 | 0.84 | TRPA1 (0.70) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6178650 | 0.84 | TRPA1 (0.62) | TRPA1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |