Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | TACR2 | P21452 | 7/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 2/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7130718 | 0.89 | ALDH1A1 (0.33) | TACR2 | |
| SCHEMBL1866180 | 0.80 | APP (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1866177 | 0.80 | APP (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1858505 | 0.78 | GAA (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1858509 | 0.78 | GAA (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1858506 | 0.78 | GAA (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2644883 | 0.78 | APP (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2644937 | 0.78 | APP (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2644230 | 0.76 | GAA (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2644229 | 0.76 | GAA (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046755-A2 | PYRAZOLES AS GLUCOKINASE ACTIVATORS | F. Hoffmann-Roche AG (CH) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008012227-A2 | PYRAZOLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-31 | — | — | WO | disclosed |