Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.74 |
| ▸ | PRKDC | P78527 | 16/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.61 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.56 |
| ▸ | MTOR | P42345 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PDE2A | O00408 | 1/20 | 0.56 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.56 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.56 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316808 | 0.85 | P2RY12 (1.00) | P2RY12 | |
| SCHEMBL7328250 | 0.82 | PRKDC (0.68) | P2RY12PRKDCPIK3CAPIK3R1MTOR | |
| SCHEMBL910153 | 0.82 | PRKDC (0.84) | P2RY12PRKDCPIK3CAPIK3R1MTOR | |
| SCHEMBL3542889 | 0.81 | PRKDC (1.00) | P2RY12PRKDCPIK3CAPIK3R1MTOR | |
| SCHEMBL7319895 | 0.81 | PRKDC (0.64) | P2RY12PRKDCPIK3CAPIK3R1MTOR | |
| SCHEMBL7317064 | 0.81 | PRKDC (0.68) | P2RY12PRKDCPIK3CAPIK3R1MTOR | |
| SCHEMBL7327041 | 0.80 | PRKDC (0.70) | P2RY12PRKDC | |
| SCHEMBL7328002 | 0.80 | P2RY12 (0.76) | P2RY12PRKDCPIK3CA | |
| SCHEMBL7326734 | 0.80 | P2RY12 (0.82) | P2RY12PRKDCPIK3CAPIK3R1MTOR | |
| SCHEMBL8882123 | 0.80 | P2RY12 (0.75) | P2RY12PRKDCPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703075-A | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-30 | — | — | US | claimed |
| WO-1991019707-A2 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1991-12-26 | — | — | WO | claimed |
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | THE UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-12-31 | — | — | US | disclosed |
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | THE UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-12-31 | — | — | US | disclosed |
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | THE UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-12-31 | — | — | US | disclosed |
| EP-2046768-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | Kudos Pharmaceuticals Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008009934-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| US-5703075-A | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-30 | — | — | US | disclosed |
| WO-1991019707-A2 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1991-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | XRN2, ASNS, CYP2B6 | P2RY12 4122/4885PRKDC 3597/4885PIK3CA 1369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.