Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL284728 | 0.77 | TSHR (0.40) | TSHRALDH1A1TP53SLC7A5CYP2D6 | |
| SCHEMBL14387795 | 0.77 | TSHR (0.40) | TSHRALDH1A1TP53SLC7A5CYP2D6 | |
| SCHEMBL2230034 | 0.75 | ALDH1A1 (0.44) | TSHRALDH1A1TP53SLC7A5CYP2D6 | |
| SCHEMBL9527915 | 0.74 | TSHR (0.38) | TSHRALDH1A1TP53SLC7A5CYP2D6 | |
| SCHEMBL28315772 | 0.73 | ALDH1A1 (0.42) | TSHRALDH1A1TP53CYP2D6CYP2C19 | |
| SCHEMBL21269260 | 0.73 | ALDH1A1 (0.42) | TSHRALDH1A1TP53CYP2D6CYP2C19 | |
| SCHEMBL21268834 | 0.73 | ALDH1A1 (0.42) | TSHRALDH1A1TP53CYP2D6CYP2C19 | |
| SCHEMBL21269388 | 0.73 | ALDH1A1 (0.42) | TSHRALDH1A1TP53CYP2D6CYP2C19 | |
| SCHEMBL28315892 | 0.73 | ALDH1A1 (0.42) | TSHRALDH1A1TP53CYP2D6CYP2C19 | |
| SCHEMBL28315846 | 0.73 | ALDH1A1 (0.42) | TSHRALDH1A1TP53CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109604-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-10-21 | — | — | EP | disclosed |
| US-7544679-B2 | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-06-09 | — | — | US | disclosed |
| WO-2008092786-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | disclosed |
| US-20080188463-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-08-07 | — | — | US | disclosed |
| EP-0019578-B1 | PIPERIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND POLYMER COMPOSITIONS CONTAINING THEM | Chimosa Chimica Organica S.p.A. (IT) | 1983-03-30 | — | — | EP | disclosed |
| EP-0019578-A1 | Piperidine derivatives, process for preparing them and polymer compositions containing them | Chimosa Chimica Organica S.p.A. (IT) | 1980-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188463-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | BACE1, BACE2, APH1B | TSHR 4173/4885ALDH1A1 795/4885TP53 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.