Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | PRCP | P42785 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 5/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3940629 | 0.84 | DRD2 (0.51) | DRD2MEN1KMT2ADRD3DRD4 | |
| Hydrochloric Acid SCHEMBL3944547 | 0.77 | DRD2 (0.49) | DRD2MEN1KMT2ADRD3DRD4 | |
| SCHEMBL27579835 | 0.76 | DRD2 (0.62) | DRD2MEN1KMT2ADRD3DRD4 | |
| Hydrochloric Acid SCHEMBL3941377 | 0.74 | DRD2 (0.56) | DRD2MEN1KMT2ADRD3DRD4 | |
| SCHEMBL3945724 | 0.74 | CCR1 (0.48) | PRCPCCR1 | |
| SCHEMBL3940847 | 0.72 | PRCP (0.41) | DRD2MEN1KMT2ADRD3DRD4 | |
| Hydrochloric Acid SCHEMBL3945178 | 0.71 | SLC18A3 (0.41) | DRD2DRD3CCR1CCR2HTR1A | |
| SCHEMBL10287616 | 0.71 | DRD2 (0.77) | DRD2MEN1KMT2ADRD3DRD4 | |
| Hydrochloric Acid SCHEMBL3941761 | 0.70 | DRD2 (0.50) | DRD2MEN1KMT2ADRD3DRD4 | |
| SCHEMBL9967731 | 0.69 | DRD2 (0.68) | DRD2MEN1KMT2ADRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049486-A2 | PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007092681-A2 | PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-16 | — | — | WO | disclosed |