Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3951093 | 0.90 | HTT (0.55) | HTTSMN1; SMN2ALDH1A1TSHRPKM | |
| SCHEMBL3943074 | 0.90 | HTT (0.53) | HTTSMN1; SMN2ALDH1A1TSHRPKM | |
| SCHEMBL3943645 | 0.90 | HTT (0.49) | HTTSMN1; SMN2ALDH1A1TSHRPKM | |
| SCHEMBL3945166 | 0.88 | HTT (0.57) | HTTSMN1; SMN2ALDH1A1TSHRPKM | |
| SCHEMBL3951125 | 0.88 | SMN1; SMN2 (0.39) | HTTSMN1; SMN2ALDH1A1TSHRPKM | |
| SCHEMBL3951486 | 0.88 | HTT (0.53) | HTTSMN1; SMN2ALDH1A1TSHRPKM | |
| SCHEMBL3947317 | 0.88 | HTT (0.56) | HTTSMN1; SMN2ALDH1A1TSHRPKM | |
| SCHEMBL3950805 | 0.88 | HTT (0.48) | HTTSMN1; SMN2ALDH1A1TSHRPKM | |
| SCHEMBL3947064 | 0.88 | CTDSP1 (0.41) | HTTTSHRLMNAKMT2AMEN1 | |
| SCHEMBL3942157 | 0.88 | TSHR (0.43) | HTTTSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |