Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8084823 | 0.82 | CNR1 (0.35) | CNR1CNR2TDP1S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL6290544 | 0.82 | CNR1 (0.35) | CNR1CNR2TDP1S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL3946480 | 0.81 | CNR1 (0.34) | CNR1CNR2TDP1S1PR1S1PR3 | |
| SCHEMBL6930680 | 0.80 | CNR1 (0.35) | CNR1CNR2TDP1P2RX1RXRA | |
| Hydrochloric Acid SCHEMBL7937854 | 0.80 | CNR1 (0.35) | CNR1CNR2TDP1S1PR1S1PR3 | |
| SCHEMBL7634910 | 0.79 | CNR1 (0.35) | CNR1CNR2TDP1S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL7928681 | 0.79 | CNR1 (0.35) | CNR1CNR2TDP1S1PR1S1PR3 | |
| SCHEMBL7632084 | 0.79 | CNR1 (0.35) | CNR1CNR2TDP1S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL7639533 | 0.78 | CNR1 (0.35) | CNR1CNR2TDP1S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL7652901 | 0.77 | CNR1 (0.35) | CNR1CNR2TDP1S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592408-B2 | Olefin copolymers containing hydrolytically cleavable linkages and use thereof in degradable products | SRI INTERNATIONAL (US) | 2009-09-22 | — | — | US | disclosed |
| US-20080227940-A1 | Olefin Copolymers Containing Hydrolytically Cleavable Linkages and Use Thereof In Degradable Products | SRI INTERNATIONAL (US) | 2008-09-18 | — | — | US | disclosed |
| US-7399817-B2 | Olefin copolymers containing hydrolytically cleavable linkages and use thereof in degradable products | SRI INTERNATIONAL (US) | 2008-07-15 | — | — | US | disclosed |
| US-7037992-B2 | Olefin copolymers containing hydrolytically cleavable linkages and use thereof in degradable products | SRI INTERNATIONAL (US) | 2006-05-02 | — | — | US | disclosed |
| US-20060079654-A1 | Olefin copolymers containing hydrolytically cleavable linkages and use thereof in degradable products | SRI INTERNATIONAL (US) | 2006-04-13 | — | — | US | disclosed |
| US-20030236371-A1 | Olefin copolymers containing hydrolytically cleavable linkages and use thereof in degradable products | SRI INTERNATIONAL | 2003-12-25 | — | — | US | disclosed |
| US-6534610-B1 | Ethylene copolymer with hydrolyzable component in backbone; prepared by transition metal complex catalyzed addition polymerization | SRI INTERNATIONAL | 2003-03-18 | — | — | US | disclosed |
| WO-2001023448-A9 | HYDROLYTICALLY DEGRADABLE OLEFIN COPOLYMERS | STANFORD RES INST INT (US) | 2002-09-26 | — | — | WO | disclosed |
| EP-1237962-A1 | HYDROLYTICALLY DEGRADABLE OLEFIN COPOLYMERS | Sri International (US) | 2002-09-11 | — | — | EP | disclosed |
| US-6288184-B1 | CATALYTIC COPOLYMERIZATION USING TRANSITION METAL METALLOCENE COMPLEX | SRI INTERNATIONAL | 2001-09-11 | — | — | US | disclosed |
| WO-2001023448-A1 | HYDROLYTICALLY DEGRADABLE OLEFIN COPOLYMERS | SRI INTERNATIONAL (US) | 2001-04-05 | — | — | WO | disclosed |