Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3952380 | 1.00 | BRD4 (0.50) | BRD4SERPINE1CA1CA2CA12 | |
| SCHEMBL3947589 | 1.00 | BRD4 (0.50) | BRD4SERPINE1CA1CA2CA12 | |
| SCHEMBL3953037 | 0.91 | BRD4 (0.52) | BRD4SERPINE1CA1CA2CA12 | |
| SCHEMBL3946187 | 0.89 | BRD4 (0.52) | BRD4SERPINE1CA1CA2CA12 | |
| SCHEMBL3952994 | 0.87 | BRD4 (0.49) | BRD4SERPINE1CA1CA2KMT2A | |
| SCHEMBL3951354 | 0.87 | BRD4 (0.49) | BRD4SERPINE1CA1CA2KMT2A | |
| SCHEMBL3944739 | 0.87 | BRD4 (0.49) | BRD4SERPINE1CA1CA2KMT2A | |
| SCHEMBL5149516 | 0.86 | CA1 (0.49) | BRD4SERPINE1CA1CA2CA12 | |
| SCHEMBL3951651 | 0.85 | HTR6 (0.47) | BRD4SERPINE1CA1CA2CA12 | |
| SCHEMBL3950163 | 0.85 | BRD4 (0.51) | BRD4SERPINE1CA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802572-B1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | BAYER SCHERING PHARMA AG (DE) | 2009-04-22 | — | — | EP | claimed |