SCHEMBL3944845

SCHEMBL3944845

CCOC(=O)c1ccccc1NN

nearest known ligand 0.69

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.69
ALDH1A1 P00352 4/20 0.64
HSD17B10 Q99714 3/20 0.64
KDM4E B2RXH2 5/20 0.63
CDC25B P30305 5/20 0.61
LMNA P02545 4/20 0.61
CDC25A P30304 1/20 0.61
CDC25C P30307 1/20 0.61
KMT2A Q03164 1/20 0.61
NPSR1 Q6W5P4 2/20 0.60
TP53 P04637 1/20 0.60
HTT P42858 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
MAPK10 P53779 1/20 0.58
HPGD P15428 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9150908 0.98 TSHR (0.67) TSHRALDH1A1HSD17B10KDM4ECDC25B
SCHEMBL28061271 0.87 TSHR (0.56) TSHRALDH1A1HSD17B10KDM4ECDC25B
SCHEMBL10438008 0.86 KDM4E (0.68) TSHRALDH1A1HSD17B10KDM4ELMNA
SCHEMBL1500584 0.86 TSHR (0.69) TSHRALDH1A1HSD17B10KDM4ECDC25B
SCHEMBL619175 0.86 TSHR (0.69) TSHRALDH1A1HSD17B10KDM4ECDC25B
Hydrochloric Acid SCHEMBL27734207 0.85 CDC25B (0.50) TSHRALDH1A1HSD17B10KDM4ECDC25B
SCHEMBL5542918 0.85 TSHR (0.62) TSHRALDH1A1HSD17B10KDM4ECDC25B
Hydrochloric Acid SCHEMBL6379948 0.84 TSHR (0.67) TSHRALDH1A1HSD17B10KDM4ECDC25B
SCHEMBL1460556 0.84 TSHR (0.67) TSHRALDH1A1HSD17B10KDM4ECDC25B
SCHEMBL8723887 0.84 TSHR (0.67) TSHRALDH1A1HSD17B10KDM4ECDC25B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105503925-B A kind of activation method of double (pinacol conjunction) diboranes and its application 南京大学 2017-07-28 CN disclosed
WO-2009017874-A9 NOVEL CURCUMIN DERIVATIVES AND THEIR PHARMACEUTICAL USES THEREOF UNIV ROCHESTER (US) 2009-03-19 WO disclosed
WO-2009023357-A2 CURCUMIN DERIVATIVES AND THEIR USE AS RADIOPROTECTORS UNIVERSITY OF ROCHESTER (US) 2009-02-19 WO disclosed
WO-2009017874-A2 NOVEL CURCUMIN DERIVATIVES AND THEIR PHARMACEUTICAL USES THEREOF UNIVERSITY OF ROCHESTER (US) 2009-02-05 WO disclosed
EP-0614898-B1 INDOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF TORAY INDUSTRIES (JP) 2003-05-07 EP disclosed
US-6291470-B1 DELTA-OPIOID ANTAGONIST HAVING HIGH SELECTIVITY AND ACTIVITY, THAT EXHIBITS IMMUNOSUPPRESSIVE ACTION, ANTIALLERGIC ACTION, ANTI-INFLAMMATORY ACTION AND BRAIN CELL-PROTECTING ACTION TORAY INDUSTRIES, INC. (JP) 2001-09-18 US disclosed
US-6087369-A AN IMMUNOSUPPRESSIVE AGENT, ANTIALLERGIC AGENT, ANTI-INFLAMMATORY AGENT AND BRAIN CELL-PROTECTING AGENT TORAY INDUSTRIES, LTD. (JP) 2000-07-11 US disclosed
CN-1043766-C Indole derivative and preparation and pharmaceutical using of same TORAY INDUSTRIES (JP) 1999-06-23 CN disclosed
US-5852030-A Indole derivatives, process for producing the same and medicinal uses of the same TORAY INDUSTRIES, INC. (JP) 1998-12-22 US disclosed
US-5661139-A FOR INHIBITING GLYCOSYLATION OF PROTEINS TO PREVENT DISCOLORATION OF THE TEETH ALTEON INC. (US) 1997-08-26 US disclosed
WO-1996040622-A1 BIS-(2-ARYL)HYDRAZONES AS INHIBITORS OF THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS ALTEON INC. (US) 1996-12-19 WO disclosed
CN-1092425-A Indole derivatives, its manufacture method and medicinal use thereof TORAY INDUSTRIES (JP) 1994-09-21 CN disclosed
EP-0614898-A1 INDOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF TORAY INDUSTRIES, INC. (JP) 1994-09-14 EP disclosed
CN-1053429-A INDOLE-SUBSTITUTED FIVE-MEMBERED HETEROAROMATIC COMPOUNDS MERCK SHARP & DOHME (GB) 1991-07-31 CN disclosed
US-4358611-A FROM A PHENYLHYDRAZINE, A CHLOROFORMATE, PHOSGENE AND A SECONDARY AMINE SHELL OIL COMPANY (US) 1982-11-09 US disclosed