SCHEMBL28061271

SCHEMBL28061271

CCOC(=O)c1cccc(NN)c1C(=O)OCC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.56
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA7 P43166 1/20 0.53
CA9 Q16790 1/20 0.53
CA14 Q9ULX7 1/20 0.53
ALDH1A1 P00352 4/20 0.53
HSD17B10 Q99714 3/20 0.53
CDC25B P30305 4/20 0.52
CDC25A P30304 1/20 0.52
CDC25C P30307 1/20 0.52
TDP1 Q9NUW8 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51
TP53 P04637 1/20 0.51
HTT P42858 1/20 0.51
KDM4E B2RXH2 5/20 0.50
LMNA P02545 4/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
HPGD P15428 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3944845 0.87 TSHR (0.69) TSHRALDH1A1HSD17B10CDC25BCDC25A
Hydrochloric Acid SCHEMBL9150908 0.85 TSHR (0.67) TSHRALDH1A1HSD17B10CDC25BCDC25A
SCHEMBL560709 0.83 TSHR (0.73) TSHRCA12CA1CA2CA7
SCHEMBL9695877 0.80 TSHR (0.50) TSHRALDH1A1HSD17B10CDC25BCDC25A
SCHEMBL2894636 0.79 ALDH1A1 (0.72) TSHRCA12CA1CA2CA7
SCHEMBL11387390 0.79 TSHR (0.49) TSHRCA12CA1CA2CA7
SCHEMBL302145 0.78 TSHR (0.66) TSHRCA12CA1CA2CA7
SCHEMBL11296630 0.77 TSHR (0.63) TSHRCA12CA1CA2CA7
SCHEMBL10882650 0.77 CA12 (0.82) TSHRCA12CA1CA2CA7
SCHEMBL2137984 0.77 TSHR (0.63) TSHRCA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105503925-A Activation method of bis(pinacolato)diborane and application thereof NANJING UNIVERSITY OF TECHNOLOGY 2016-04-20 CN disclosed