Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.32 |
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
| ▸ | BRS3 | P32247 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940363 | 0.84 | HTT (0.41) | HTTPDPK1KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL3944813 | 0.82 | HTT (0.40) | HTTPDPK1KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL3946210 | 0.81 | HTT (0.41) | HTTPDPK1KDM4EHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3937247 | 0.81 | HTT (0.41) | HTTPDPK1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL7118856 | 0.79 | HTT (0.43) | HTTPDPK1KDM4EALOX15SMN1; SMN2 | |
| SCHEMBL3937914 | 0.79 | ALDH1A1 (0.50) | HTTPDPK1KDM4EALOX15SMN1; SMN2 | |
| SCHEMBL13843369 | 0.79 | KDM4E (0.43) | HTTEIF4EBP1KDM4EALOX15SMN1; SMN2 | |
| SCHEMBL3938582 | 0.78 | KDM4E (0.42) | KDM4EALOX15SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL3943935 | 0.77 | KDM4E (0.36) | HTTKDM4EHSD17B10ALDH1A1PIM1 | |
| SCHEMBL3938948 | 0.76 | HTT (0.48) | HTTGRIA4PDPK1GRIA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528140-B2 | Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors | TEIJIN LIMITED (JP) | 2009-05-05 | — | — | US | disclosed |
| US-20050277773-A1 | Pyrrolopyrimidine derivatives | TEIJIN LIMITED (JP) | 2005-12-15 | — | — | US | disclosed |
| EP-1477489-A1 | PYRROLOPYRIMIDINE DERIVATIVES | TEIJIN LIMITED (JP) | 2004-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277773-A1 | Pyrrolopyrimidine derivatives | GSK3B, GSK3A, GSKIP | HTT 3815/4885IP6K1 880/4885GRIA4 882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.